Biofilm Protocol Optimization For Pseudomonas aeruginosa

Multiple biofilm-specific mechanisms, poor antibiotic penetration, nutrient limitation, slow growth, adaptive stress responses, and formation of persister cells contribute to the high levels of antibiotic resistance. Therefore, P. aeruginosa biofilm-associated infections, such as those common in cystic fibrosis and burn patients, present huge clinical challenges which have spurred interest in the development of novel drugs and drug delivery strategies to treat these infections.